Dataset Information

Network Analysis of Murine Cortical Dynamics Implicates Untuned Neurons in Visual Stimulus Coding.

ABSTRACT: Unbiased and dense sampling of large populations of layer 2/3 pyramidal neurons in mouse primary visual cortex (V1) reveals two functional sub-populations: neurons tuned and untuned to drifting gratings. Whether functional interactions between these two groups contribute to the representation of visual stimuli is unclear. To examine these interactions, we summarize the population partial pairwise correlation structure as a directed and weighted graph. We find that tuned and untuned neurons have distinct topological properties, with untuned neurons occupying central positions in functional networks (FNs). Implementation of a decoder that utilizes the topology of these FNs yields accurate decoding of visual stimuli. We further show that decoding performance degrades comparably following manipulations of either tuned or untuned neurons. Our results demonstrate that untuned neurons are an integral component of V1 FNs and suggest that network interactions contain information about the stimulus that is accessible to downstream elements.

SUBMITTER: Levy M

PROVIDER: S-EPMC7218481 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Publications

Network Analysis of Murine Cortical Dynamics Implicates Untuned Neurons in Visual Stimulus Coding.

Levy Maayan M Sporns Olaf O MacLean Jason N JN

Cell reports 20200401 2

Unbiased and dense sampling of large populations of layer 2/3 pyramidal neurons in mouse primary visual cortex (V1) reveals two functional sub-populations: neurons tuned and untuned to drifting gratings. Whether functional interactions between these two groups contribute to the representation of visual stimuli is unclear. To examine these interactions, we summarize the population partial pairwise correlation structure as a directed and weighted graph. We find that tuned and untuned neurons have ...[more]

PMID: 32294431

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Project description:Various types of neural-based signals, such as EEG, local field potentials and intracellular synaptic potentials, integrate multiple sources of activity distributed across large assemblies. They have in common a power-law frequency-scaling structure at high frequencies, but it is still unclear whether this scaling property is dominated by intrinsic neuronal properties or by network activity. The latter case is particularly interesting because if frequency-scaling reflects the network state it could be used to characterize the functional impact of the connectivity. In intracellularly recorded neurons of cat primary visual cortex in vivo, the power spectral density of V(m) activity displays a power-law structure at high frequencies with a fractional scaling exponent. We show that this exponent is not constant, but depends on the visual statistics used to drive the network. To investigate the determinants of this frequency-scaling, we considered a generic recurrent model of cortex receiving a retinotopically organized external input. Similarly to the in vivo case, our in computo simulations show that the scaling exponent reflects the correlation level imposed in the input. This systematic dependence was also replicated at the single cell level, by controlling independently, in a parametric way, the strength and the temporal decay of the pairwise correlation between presynaptic inputs. This last model was implemented in vitro by imposing the correlation control in artificial presynaptic spike trains through dynamic-clamp techniques. These in vitro manipulations induced a modulation of the scaling exponent, similar to that observed in vivo and predicted in computo. We conclude that the frequency-scaling exponent of the V(m) reflects stimulus-driven correlations in the cortical network activity. Therefore, we propose that the scaling exponent could be used to read-out the "effective" connectivity responsible for the dynamical signature of the population signals measured at different integration levels, from Vm to LFP, EEG and fMRI.

Dataset Information

Network Analysis of Murine Cortical Dynamics Implicates Untuned Neurons in Visual Stimulus Coding.

Publications

Network Analysis of Murine Cortical Dynamics Implicates Untuned Neurons in Visual Stimulus Coding.

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