Ontology highlight
ABSTRACT:
SUBMITTER: Tai W
PROVIDER: S-EPMC7219369 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Tai Wanbo W Zhang Xiujuan X He Yuxian Y Jiang Shibo S Du Lanying L
Antiviral research 20200513
SARS-CoV-2-caused COVID-19 cases are growing globally, calling for developing effective therapeutics to control the current pandemic. SARS-CoV-2 and SARS-CoV recognize angiotensin-converting enzyme 2 (ACE2) receptor via the receptor-binding domain (RBD). Here, we identified six SARS-CoV RBD-specific neutralizing monoclonal antibodies (nAbs) that cross-reacted with SARS-CoV-2 RBD, two of which, 18F3 and 7B11, neutralized SARS-CoV-2 infection. 18F3 recognized conserved epitopes on SARS-CoV and SAR ...[more]