Dataset Information

Genetic clustering analysis for HIV infection among MSM in Nigeria: implications for intervention.

ABSTRACT:

Background

The HIV epidemic continues to grow among MSM in countries across sub-Saharan Africa including Nigeria. To inform prevention efforts, we used a phylogenetic cluster method to characterize HIV genetic clusters and factors associated with cluster formation among MSM living with HIV in Nigeria.

Methods

We analyzed HIV-1 pol sequences from 417 MSM living with HIV enrolled in the TRUST/RV368 cohort between 2013 and 2017 in Abuja and Lagos, Nigeria. A genetically linked cluster was defined among participants whose sequences had pairwise genetic distance of 1.5% or less. Binary and multinomial logistic regressions were used to estimate adjusted odds ratios (AORs) and 95% confidence intervals (CIs) for factors associated with HIV genetic cluster membership and size.

Results

Among 417 MSM living with HIV, 153 (36.7%) were genetically linked. Participants with higher viral load (AOR?=?1.72 95% CI: 1.04-2.86), no female partners (AOR?=?3.66; 95% CI: 1.97-6.08), and self-identified as male sex (compared with self-identified as bigender) (AOR?=?3.42; 95% CI: 1.08-10.78) had higher odds of being in a genetic cluster. Compared with unlinked participants, MSM who had high school education (AOR?=?23.84; 95% CI: 2.66-213.49), were employed (AOR?=?3.41; 95% CI: 1.89-10.70), had bacterial sexually transmitted infections (AOR?=?3.98; 95% CI: 0.89-17.22) and were not taking antiretroviral therapy (AOR?=?6.61; 95% CI: 2.25-19.37) had higher odds of being in a large cluster (size?>?4).

Conclusion

Comprehensive HIV prevention packages should include behavioral and biological components, including early diagnosis and treatment of both HIV and bacterial sexually transmitted infections to optimally reduce the risk of HIV transmission and acquisition.

SUBMITTER: Li Y

PROVIDER: S-EPMC7219556 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Publications

Genetic clustering analysis for HIV infection among MSM in Nigeria: implications for intervention.

Li Yuruo Y Liu Hongjie H Ramadhani Habib O HO Ndembi Nicaise N Crowell Trevor A TA Kijak Gustavo G Robb Merlin L ML Ake Julie A JA Kokogho Afoke A Nowak Rebecca G RG Gaydos Charlotte C Baral Stefan D SD Volz Erik E Tovanabutra Sodsai S Charurat Man M

AIDS (London, England) 20200201 2

<h4>Background</h4>The HIV epidemic continues to grow among MSM in countries across sub-Saharan Africa including Nigeria. To inform prevention efforts, we used a phylogenetic cluster method to characterize HIV genetic clusters and factors associated with cluster formation among MSM living with HIV in Nigeria.<h4>Methods</h4>We analyzed HIV-1 pol sequences from 417 MSM living with HIV enrolled in the TRUST/RV368 cohort between 2013 and 2017 in Abuja and Lagos, Nigeria. A genetically linked cluste ...[more]

PMID: 31634185

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Project description:BackgroundConcurrent sexually transmitted infections (STIs) are common in sexually active populations. We aimed to estimate the prevalence and coinfection rates of bacterial STIs among sexually active, HIV-positive men who have sex with men (MSM), and to assess the potential benefits of different combination treatment regimens in managing concurrent bacterial STIs.MethodsFrom September 2021 to September 2023, HIV-positive MSM underwent STI testing when they had symptoms suggestive of STIs or recently acquired hepatitis C virus (HCV) infection or early syphilis. The oral rinse, rectal swab, and urethral swab specimens were tested for Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma spp., Ureaplasma spp., and Trichomonas vaginalis with the use of multiplex real-time polymerase-chain-reaction assays. The estimated coinfection rates were used to evaluate the benefits of different combination treatment regimens for managing coinfections.ResultsDuring the study period, 535 participants (median age, 37 years; and CD4 count, 615 cells/mm3) were enrolled. On their first visits, at least one bacterial pathogen was detected in 57.9% and concomitant bacterial infections were found in 32.9% of the participants. The most commonly identified pathogen was U. urealyticum (36.3%), followed by C. trachomatis (22.8%), and N. gonorrhoeae (19.8%). The factors associated with any bacterial STIs included older age (per 1-year increase, adjusted odds ratio [AOR], 0.97; 95% confidence interval [CI], 0.95-1.00), early syphilis (AOR, 1.87; 95% CI, 1.22-2.84), and having more than 5 sex partners in the preceding 3 months (AOR, 2.08, 95% CI, 1.07-4.06). A combination therapy of benzathine penicillin G with a 7-day course of doxycycline could simultaneously treat 27.1% of C. trachomatis coinfections in participants with early syphilis, while a combination therapy of ceftriaxone with doxycycline could simultaneously treat 40.6% of chlamydial coinfections in participants with gonorrhea.ConclusionBacterial STIs were prevalent and concomitant infections were not uncommon among sexually active, HIV-positive MSM, supporting regular screening for bacterial STIs. The effectiveness of preemptive use of doxycycline as combination therapy for concurrent STIs warrants more investigations.

Dataset Information

Genetic clustering analysis for HIV infection among MSM in Nigeria: implications for intervention.

Background

Methods

Results

Conclusion

Publications

Genetic clustering analysis for HIV infection among MSM in Nigeria: implications for intervention.

Similar Datasets

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