Ontology highlight
ABSTRACT:
SUBMITTER: Song HD
PROVIDER: S-EPMC7220283 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Song Hyun-Doo HD Kim Sang Nam SN Saha Abhirup A Ahn Sang-Yeop SY Akindehin Seun S Son Yeonho Y Cho Yoon Keun YK Kim MinSu M Park Ji-Hyun JH Jung Young-Suk YS Lee Yun-Hee YH
Aging and disease 20200509 3
Aging-related adipose tissue dysfunction contributes to the progression of chronic metabolic diseases. We investigated the role of age-dependent expression of a neurotrophin, brain-derived neurotrophic factor (BDNF) in adipose tissue. Pro-BDNF expression was elevated in epididymal white adipose tissue (eWAT) with advanced age, which was associated with the reduction in sympathetic innervation. Interestingly, BDNF expression was enriched in PDGFRα<sup>+</sup> adipocyte progenitors isolated from e ...[more]