Ontology highlight
ABSTRACT:
SUBMITTER: Zhao XY
PROVIDER: S-EPMC7220368 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Zhao Xu-Yun XY Zhou Linkang L Chen Zhimin Z Ji Yewei Y Peng Xiaoling X Qi Ling L Li Siming S Lin Jiandie D JD
Science advances 20200513 20
Depletion of fat-resident regulatory T cells (T<sub>regs</sub>) and group 2 innate lymphoid cells (ILC2s) has been causally linked to obesity-associated insulin resistance. However, the molecular nature of the pathogenic signals suppress adipose T<sub>regs</sub> and ILC2s in obesity remains unknown. Here, we identified the soluble isoform of interleukin (IL)-33 receptor ST2 (sST2) as an obesity-induced adipokine that attenuates IL-33 signaling and disrupts T<sub>reg</sub>/ILC2 homeostasis in adi ...[more]