Ontology highlight
ABSTRACT:
SUBMITTER: Long J
PROVIDER: S-EPMC7531880 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Science advances 20200923 39
Dysregulation of T cell apoptosis contributes to the pathogenesis of acute systemic inflammation-induced immunosuppression, as seen in sepsis and trauma. However, the regulatory mechanisms of T cell apoptosis are unclear. Activation of stimulator of interferon genes (STING) has been shown to induce T cell apoptosis. Notch was previously identified as the top negative regulator of STING in macrophages through a kinase inhibitor library screening. However, how Notch signaling regulates STING activ ...[more]