Ontology highlight
ABSTRACT:
SUBMITTER: Krzywik J
PROVIDER: S-EPMC7221574 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20200414 8
Colchicine is a well-known compound with strong antiproliferative activity that has had limited use in chemotherapy because of its toxicity. In order to create more potent anticancer agents, a series of novel colchicine derivatives have been obtained by simultaneous modification at C7 (amides and sulfonamides) and at C10 (methylamino group) positions and characterized by spectroscopic methods. All the synthesized compounds have been tested in vitro to evaluate their cytotoxicity toward A549, MCF ...[more]