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First Example of Catalytic Synthesis of Cyclic S-Containing Di- and Triperoxides.

ABSTRACT: An efficient method for the synthesis of tetraoxathiaspiroalkanes, tetraoxathiocanes, and hexaoxathiadispiroalkanes was developed by reactions of pentaoxacanes, pentaoxaspiroalkanes, and heptaoxadispiroalkanes with hydrogen sulfide in the presence of a catalyst, Sm(NO3)3·6H2O. We found that the synthesized S-containing di- and triperoxides exhibit high cytotoxic activity against Jurkat, K562, U937, and HL60 tumor cultures, and fibroblasts.

SUBMITTER: Makhmudiyarova N

PROVIDER: S-EPMC7221664 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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First Example of Catalytic Synthesis of Cyclic S-Containing Di- and Triperoxides.

Makhmudiyarova Nataliya N Ishmukhametova Irina I Dzhemileva Lilya L D'yakonov Vladimir V Ibragimov Askhat A Dzhemilev Usein U

Molecules (Basel, Switzerland) 20200418 8

An efficient method for the synthesis of tetraoxathiaspiroalkanes, tetraoxathiocanes, and hexaoxathiadispiroalkanes was developed by reactions of pentaoxacanes, pentaoxaspiroalkanes, and heptaoxadispiroalkanes with hydrogen sulfide in the presence of a catalyst, Sm(NO3)3·6H2O. We found that the synthesized S-containing di- and triperoxides exhibit high cytotoxic activity against Jurkat, K562, U937, and HL60 tumor cultures, and fibroblasts. ...[more]

PMID: 32325665

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