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Catalytic asymmetric synthesis of cyclic sulfamides from conjugated dienes.

ABSTRACT: This paper describes the catalytic asymmetric diamination of alkyl dienes using N,N'-di-tert-butylthiadiaziridine 1,1-dioxide in the presence of Pd(0) and a chiral phosphoramidite ligand to give cyclic sulfamides in high yield and high ee. The diamination is also amenable to gram scale.

SUBMITTER: Cornwall RG

PROVIDER: S-EPMC3587789 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Catalytic asymmetric synthesis of cyclic sulfamides from conjugated dienes.

Cornwall Richard G RG Zhao Baoguo B Shi Yian Y

Organic letters 20130130 4

This paper describes the catalytic asymmetric diamination of alkyl dienes using N,N'-di-tert-butylthiadiaziridine 1,1-dioxide in the presence of Pd(0) and a chiral phosphoramidite ligand to give cyclic sulfamides in high yield and high ee. The diamination is also amenable to gram scale. ...[more]

PMID: 23362985

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