Ontology highlight
ABSTRACT:
SUBMITTER: Adorisio S
PROVIDER: S-EPMC7221903 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Adorisio Sabrina S Giamperi Laura L Bucchini Anahi Elena Ada AEA Delfino Domenico Vittorio DV Marcotullio Maria Carla MC
Molecules (Basel, Switzerland) 20200420 8
<i>Limbarda crithmoides</i> (L.) Dumort (Asteraceae) <i>n</i>-hexane extract displayed high cell proliferation inhibitory activity against acute myeloid leukaemia cells (OCI-AML3) and was therefore subjected to a bioassay-guided multistep separation procedure. Two thymol derivatives, namely 10-acetoxy-8,9-epoxythymol tiglate (<b>1</b>) and 10-acetoxy-9-chloro-8,9-dehydrothymol (<b>2</b>), were isolated and identified by means of NMR spectroscopy. Both of them exhibited a significant dose-depende ...[more]