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Bioassay-Guided Isolation of Antiproliferative Compounds from Limbarda crithmoides (L.) Dumort.


ABSTRACT: Limbarda crithmoides (L.) Dumort (Asteraceae) n-hexane extract displayed high cell proliferation inhibitory activity against acute myeloid leukaemia cells (OCI-AML3) and was therefore subjected to a bioassay-guided multistep separation procedure. Two thymol derivatives, namely 10-acetoxy-8,9-epoxythymol tiglate (1) and 10-acetoxy-9-chloro-8,9-dehydrothymol (2), were isolated and identified by means of NMR spectroscopy. Both of them exhibited a significant dose-dependent inhibition of cell proliferation.

SUBMITTER: Adorisio S 

PROVIDER: S-EPMC7221903 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Bioassay-Guided Isolation of Antiproliferative Compounds from <i>Limbarda crithmoides</i> (L.) Dumort.

Adorisio Sabrina S   Giamperi Laura L   Bucchini Anahi Elena Ada AEA   Delfino Domenico Vittorio DV   Marcotullio Maria Carla MC  

Molecules (Basel, Switzerland) 20200420 8


<i>Limbarda crithmoides</i> (L.) Dumort (Asteraceae) <i>n</i>-hexane extract displayed high cell proliferation inhibitory activity against acute myeloid leukaemia cells (OCI-AML3) and was therefore subjected to a bioassay-guided multistep separation procedure. Two thymol derivatives, namely 10-acetoxy-8,9-epoxythymol tiglate (<b>1</b>) and 10-acetoxy-9-chloro-8,9-dehydrothymol (<b>2</b>), were isolated and identified by means of NMR spectroscopy. Both of them exhibited a significant dose-depende  ...[more]

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