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Prdx6 Plays a Main Role in the Crosstalk Between Aging and Metabolic Sarcopenia.

ABSTRACT: With the increase in average life expectancy, several individuals are affected by age-associated non-communicable chronic diseases (NCDs). The presence of NCDs, such as type 2 diabetes mellitus (T2DM), leads to the reduction in skeletal muscle mass, a pathological condition defined as sarcopenia. A key factor linking sarcopenia with cellular senescence and diabetes mellitus (DM) is oxidative stress. We previously reported as the absence of Peroxiredoxin 6 (Prdx6), an antioxidant enzyme implicated in maintaining intracellular redox homeostasis, induces an early-stage of T2DM. In the present study we sought to understand the role of Prdx6 in the crosstalk between aging and diabetic sarcopenia, by using Prdx6 knockout (Prdx6-/-) mice. Absence of Prdx6 reduced telomeres length and Sirtuin1 (SIRT1) nuclear localization. An increase in Sa-?-Gal activity and p53-p21 pro-aging pathway were also evident. An impairment in IGF-1 (Insulin-like Groth Factor-1)/Akt-1/mTOR pathway leading to a relative increase in Forkhead Box O1 (FOXO1) nuclear localization and in a decrease of muscle differentiation as per lower levels of myoblast determination protein 1 (MyoD) was observed. Muscle atrophy was also present in Prdx6-/- mice by the increase in Muscle RING finger 1 (MuRF1) levels and proteins ubiquitination associated to a reduction in muscle strength. The present study, innovatively, highlights a fundamental role of Prdx6, in the crosstalk between aging, sarcopenia, and DM.

SUBMITTER: Pacifici F

PROVIDER: S-EPMC7222359 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Prdx6 Plays a Main Role in the Crosstalk Between Aging and Metabolic Sarcopenia.

Pacifici Francesca F Della-Morte David D Piermarini Francesca F Arriga Roberto R Scioli Maria Giovanna MG Capuani Barbara B Pastore Donatella D Coppola Andrea A Rea Silvia S Donadel Giulia G Andreadi Aikaterini A Abete Pasquale P Sconocchia Giuseppe G Bellia Alfonso A Orlandi Augusto A Lauro Davide D

Antioxidants (Basel, Switzerland) 20200417 4

With the increase in average life expectancy, several individuals are affected by age-associated non-communicable chronic diseases (NCDs). The presence of NCDs, such as type 2 diabetes mellitus (T2DM), leads to the reduction in skeletal muscle mass, a pathological condition defined as sarcopenia. A key factor linking sarcopenia with cellular senescence and diabetes mellitus (DM) is oxidative stress. We previously reported as the absence of Peroxiredoxin 6 (Prdx6), an antioxidant enzyme implicate ...[more]

PMID: 32316601

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Dataset Information

Prdx6 Plays a Main Role in the Crosstalk Between Aging and Metabolic Sarcopenia.

Publications

Prdx6 Plays a Main Role in the Crosstalk Between Aging and Metabolic Sarcopenia.

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