Ontology highlight
ABSTRACT:
SUBMITTER: Smith MA
PROVIDER: S-EPMC7670064 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Smith Molly A MA Culver-Cochran Ashley E AE Adelman Emmalee R ER Rhyasen Garrett W GW Ma Averil A Figueroa Maria E ME Starczynowski Daniel T DT
Frontiers in immunology 20201103
Hematopoietic stem and progenitor cells (HSPC) experience a functional decline in response to chronic inflammation or aging. Haploinsufficiency of A20, or TNFAIP3, an innate immune regulator, is associated with a variety of autoimmune, inflammatory, and hematologic malignancies. Based on a prior analysis of epigenomic and transcriptomic changes during normal human aging, we find that the expression of A20 is significantly reduced in aged HSPC as compared to young HSPC. Here, we show that the par ...[more]