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Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain.

ABSTRACT: BACKGROUND:Health-related quality of life (HRQoL) is impaired in patients with stable angina but patients often present with other forms of chest pain. The aim of this study was to compare the pre-diagnostic HRQoL in patients with suspected coronary artery disease (CAD) according to angina type, gender, and presence of obstructive CAD. METHODS:From the pilot study for the European DISCHARGE trial, we analysed data from 24 sites including 1263 patients (45.9% women, 61.1?±?11.3?years) who were clinically referred for invasive coronary angiography (ICA; 617 patients) or coronary computed tomography angiography (CTA; 646 patients). Prior to the procedures, patients completed HRQoL questionnaires: the Short Form (SF)-12v2, the EuroQoL (EQ-5D-3?L) and the Hospital Anxiety and Depression Scale. RESULTS:Fifty-five percent of ICA and 35% of CTA patients had typical angina, 23 and 33% had atypical angina, 18 and 28% had non-anginal chest discomfort and 5 and 5% had other chest discomfort, respectively. Patients with typical angina had the poorest physical functioning compared to the other angina groups (SF-12 physical component score; 41.2?±?8.8, 43.3?±?9.1, 46.2?±?9.0, 46.4?±?11.4, respectively, all age and gender-adjusted p?

SUBMITTER: Rieckmann N

PROVIDER: S-EPMC7222590 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain.

Rieckmann Nina N Neumann Konrad K Feger Sarah S Ibes Paolo P Napp Adriane A Preuß Daniel D Dreger Henryk H Feuchtner Gudrun G Plank Fabian F Suchánek Vojtěch V Veselka Josef J Engstrøm Thomas T Kofoed Klaus F KF Schröder Stephen S Zelesny Thomas T Gutberlet Matthias M Woinke Michael M Maurovich-Horvat Pál P Merkely Béla B Donnelly Patrick P Ball Peter P Dodd Jonathan D JD Hensey Mark M Loi Bruno B Saba Luca L Francone Marco M Mancone Massimo M Berzina Marina M Erglis Andrejs A Vaitiekiene Audrone A Zajanckauskiene Laura L Harań Tomasz T Suckiel Malgorzata Ilnicka MI Faria Rita R Gama-Ribeiro Vasco V Benedek Imre I Rodean Ioana I Adjić Filip F Čemerlić Adjić Nada N Rodriguez-Palomares José J Garcia Del Blanco Bruno B Brooksbank Katriona K Collison Damien D Davis Gershan G Thwaite Erica E Knuuti Juhani J Saraste Antti A Kępka Cezary C Kruk Mariusz M Benedek Theodora T Ratiu Mihaela M Neskovic Aleksandar N AN Vidakovic Radosav R Diez Ignacio I Lecumberri Iñigo I Fisher Michael M Ruzsics Balazs B Hollingworth William W Gutiérrez-Ibarluzea Iñaki I Dewey Marc M Müller-Nordhorn Jacqueline J

Health and quality of life outcomes 20200514 1

<h4>Background</h4>Health-related quality of life (HRQoL) is impaired in patients with stable angina but patients often present with other forms of chest pain. The aim of this study was to compare the pre-diagnostic HRQoL in patients with suspected coronary artery disease (CAD) according to angina type, gender, and presence of obstructive CAD.<h4>Methods</h4>From the pilot study for the European DISCHARGE trial, we analysed data from 24 sites including 1263 patients (45.9% women, 61.1 ± 11.3 yea ...[more]

PMID: 32410687

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Project description:BackgroundPatients with noncardiac chest pain (NCCP) report more severe symptoms and lowered health-related quality of life when they present with comorbid panic disorder (PD). Although generalized anxiety disorder (GAD) is the second most common psychiatric disorder in these patients, its impact on NCCP and health-related quality of life remains understudied. This study describes and prospectively compares patients with NCCP with or without PD or GAD in terms of (1) NCCP severity; and (2) the physical and mental components of health-related quality of life.MethodsA total of 915 patients with NCCP were consecutively recruited in two emergency departments. The presence of comorbid PD or GAD was assessed at baseline with the Anxiety Disorder Schedule for DSM-IV. NCCP severity at baseline and at the six-month follow-up was assessed with a structured telephone interview, and the patients completed the 12-item Short-Form Health Survey Version 2 (SF-12v2) to assess health-related quality of life at both time points.ResultsAverage NCCP severity decreased between baseline and the six-month follow-up (p < .001) and was higher in the patients with comorbid PD or GAD (p < .001) at both time points compared to those with NCCP only. However, average NCCP severity did not differ between patients with PD and those with GAD (p = 0.901). The physical component of quality of life improved over time (p = 0.016) and was significantly lower in the subset of patients with PD with or without comorbid GAD compared to the other groups (p < .001). A significant time x group interaction was found for the mental component of quality of life (p = 0.0499). GAD with or without comorbid PD was associated with a lower mental quality of life, and this effect increased at the six-month follow-up.ConclusionsComorbid PD or GAD are prospectively associated with increased chest pain severity and lowered health-related quality of life in patients with NCCP. PD appears to be mainly associated with the physical component of quality of life, while GAD has a greater association with the mental component. Knowledge of these differences could help in the management of patients with NCCP and these comorbidities.

Project description:OBJECTIVES: To compare health-related quality of life (HRQoL) between patients with stable angina and the general population in China and to examine factors associated with HRQoL among patients with stable angina. METHODS: A cross-sectional HRQoL survey of stable angina patients recruited from 4 hospitals (n = 411) and the general population recruited from 3 Physical Examination Centers (n = 549) was conducted from July to December, 2011 in two large cities, Tianjin and Chengdu. HRQoL was assessed using the EQ-5D, EQ-VAS, and SF-6D instruments. The health status specific to patients with stable angina was assessed using the Seattle Angina Questionnaire (SAQ). Information on socio-demographic, clinical, and lifestyle factors were also collected. Nested regressions were performed to explore how these factors were associated with HRQoL in patients with stable angina. RESULTS: Compared with the general population (44.2 ± 10 years, 49.9% females), stable angina patients (68.1 ± 12 years, 50.4% females) had significantly lower HRQoL scores in EQ-5D utility index (0.75 ± 0.19 vs. 0.90 ± 0.20, p<0.05), SF-6D utility index (0.68 ± 0.12 vs. 0.85 ± 0.11, p<0.05), and EQ-VAS (71.2 ± 12.3 vs. 83.9 ± 10.9, p<0.05). The differences remained (-0.05 for EQ-5D, -9.27 for EQ-VAS and -0.13 for SF-6D) after controlling for socio-economic characteristics. SAQ scores showed that stable angina patients experienced impaired disease-specific health status, especially in angina stability (40.5 ± 34.6). Nested regressions indicated stable angina-specific health status explained most of the variation in HRQoL, among which disease perception, physical limitation, and angina stability were the strongest predictors. More physical exercise and better sleep were positively related with HRQoL. CONCLUSIONS: Compared to the general population, stable angina patients were associated with lower HRQoL and lower health utility scores, which were largely impacted by clinical symptoms. Further studies are needed to characterize the influence of geographic and cultural factors on the variations of health-related utility in stable angina patients.

Dataset Information

Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain.

Publications

Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain.

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