Ontology highlight
ABSTRACT:
SUBMITTER: Roskin KM
PROVIDER: S-EPMC7223457 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Nature immunology 20200120 2
A goal of HIV vaccine development is to elicit antibodies with neutralizing breadth. Broadly neutralizing antibodies (bNAbs) to HIV often have unusual sequences with long heavy-chain complementarity-determining region loops, high somatic mutation rates and polyreactivity. A subset of HIV-infected individuals develops such antibodies, but it is unclear whether this reflects systematic differences in their antibody repertoires or is a consequence of rare stochastic events involving individual clon ...[more]