Neutralizing Antibody-Based Prevention of Cell-Associated HIV-1 Infection.
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ABSTRACT:
SUBMITTER: Parsons MS
PROVIDER: S-EPMC6024846 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Neutralizing Antibody-Based Prevention of Cell-Associated HIV-1 Infection.
Parsons Matthew S MS Le Grand Roger R Kent Stephen J SJ
Viruses 20180618 6
Improved vaccine-mediated protection against HIV-1 requires a thorough understanding of the mode of HIV-1 transmission and how various immune responses control transmission. Cell-associated HIV-1 is infectious and contributes to HIV-1 transmission in humans. Non-human primate models of cell-associated SIV infection demonstrate that cell-associated SIV is more infectious than cell-free SIV. In a recently described chimeric simian⁻human immunodeficiency virus (SHIV) macaque model, it was demonstra ...[more]
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