Unknown

Dataset Information

0

COVID-19 and the role of chronic inflammation in patients with obesity.


ABSTRACT: Coronavirus disease 2019 (COVID-19) and the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a particular risk to people living with preexisting conditions that impair immune response or amplify pro-inflammatory response. Low-grade chronic systemic inflammation, common in people with obesity, is associated with the development of atherosclerosis, type 2 diabetes, and hypertension, well known comorbidities that adversely affect the outcomes of patients with COVID-19. Risk stratification based on the Edmonton Obesity Staging System (EOSS), which classifies obesity based on the presence of medical, mental, and/or functional complications rather than on body mass index (BMI), has been shown to be a better predictor of all-cause mortality and it may well be that EOSS stages may better describe the risk of hyperinflammation in patients with COVID-19 infection. Analyzing a group of metabolic ill patients with obesity (EOSS 2 and 3), we found an increased interleukin-6 and linear regression analysis showed a positive correlation with C-reactive protein (CRP) (p?=?0.014) and waist-to-hip-ratio (WHR) (p?=?0.031). Physicians should be aware of these findings in patients with COVID-19 infection. Early identification of possible hyperinflammation could be fundamental and should guide decision making regarding hospitalization, early respiratory support, and therapy with immunosuppression to improve mortality.

SUBMITTER: Chiappetta S 

PROVIDER: S-EPMC7224343 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

COVID-19 and the role of chronic inflammation in patients with obesity.

Chiappetta Sonja S   Sharma Arya M AM   Bottino Vincenzo V   Stier Christine C  

International journal of obesity (2005) 20200514 8


Coronavirus disease 2019 (COVID-19) and the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a particular risk to people living with preexisting conditions that impair immune response or amplify pro-inflammatory response. Low-grade chronic systemic inflammation, common in people with obesity, is associated with the development of atherosclerosis, type 2 diabetes, and hypertension, well known comorbidities that adversely affect the outcomes of patients with COVID-19. Ris  ...[more]

Similar Datasets

| S-EPMC8901184 | biostudies-literature
| S-BSST416 | biostudies-other
2023-08-21 | GSE233732 | GEO
| S-EPMC7399077 | biostudies-literature
| S-BSST1269 | biostudies-other
| S-EPMC7201395 | biostudies-literature
| S-EPMC7675904 | biostudies-literature
| S-BSST719 | biostudies-other
2023-07-26 | GSE227585 | GEO
| S-EPMC7326443 | biostudies-literature