Ontology highlight
ABSTRACT:
SUBMITTER: Smith EC
PROVIDER: S-EPMC7224506 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Smith Emily C EC Limbach Keith J KJ Rangel Nonenipha N Oda Kyosuke K Bolton Jessica S JS Du Mengyan M Gowda Kalpana K Wang Jianyang J Moch J Kathleen JK Sonawane Sharvari S Velasco Rachel R Belmonte Arnel A Danner Rebecca R Lumsden Joanne M JM Patterson Noelle B NB Sedegah Martha M Hollingdale Michael R MR Richie Thomas L TL Sacci John B JB Villasante Eileen D ED Aguiar Joao C JC
PloS one 20200514 5
Only a small fraction of the antigens expressed by malaria parasites have been evaluated as vaccine candidates. A successful malaria subunit vaccine will likely require multiple antigenic targets to achieve broad protection with high protective efficacy. Here we describe protective efficacy of a novel antigen, Plasmodium yoelii (Py) E140 (PyE140), evaluated against P. yoelii challenge of mice. Vaccines targeting PyE140 reproducibly induced up to 100% sterile protection in both inbred and outbred ...[more]