Blood platelets contain tumor-derived RNA biomarkers.
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ABSTRACT:
SUBMITTER: Nilsson RJ
PROVIDER: S-EPMC7224637 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
Blood platelets contain tumor-derived RNA biomarkers.
Nilsson R Jonas A RJ Balaj Leonora L Hulleman Esther E van Rijn Sjoerd S Pegtel D Michiel DM Walraven Maudy M Widmark Anders A Gerritsen Winald R WR Verheul Henk M HM Vandertop W Peter WP Noske David P DP Skog Johan J Würdinger Thomas T
Blood 20110810 13
Diagnostic platforms providing biomarkers that are highly predictive for diagnosing, monitoring, and stratifying cancer patients are key instruments in the development of personalized medicine. We demonstrate that tumor cells transfer (mutant) RNA into blood platelets in vitro and in vivo, and show that blood platelets isolated from glioma and prostate cancer patients contain the cancer-associated RNA biomarkers EGFRvIII and PCA3, respectively. In addition, gene-expression profiling revealed a d ...[more]
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