Prognostic factors and outcome of reirradiation for locally recurrent small cell lung cancer-a multicenter study.

ABSTRACT:

Background

The prognosis of patients with recurrent small cell lung cancer (SCLC) remains poor and treatment options are limited. We performed a multi-institution retrospective cohort study to evaluate the outcome of thoracic reirradiation, identify prognostic factors and assess treatment-related toxicity.

Methods

Data of 33 patients re-irradiated for recurrent SCLC at 4 international university hospitals, were analysed. Overall survival (OS) acute and late toxicities were evaluated and prognostic factors for reirradiation were identified.

Results

Reirradiation (Re-RT) was performed at a median interval time of 24 months after the first thoracic radiotherapy series. Median survival after reirradiation was 7 months (range, 1-54 months). The Re-RT dose in EQD2 ranged fr

SUBMITTER: Kasmann L 

PROVIDER: S-EPMC7225148 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature