A Bitter Taste in Your Heart.
Ontology highlight
ABSTRACT:
SUBMITTER: Bloxham CJ
PROVIDER: S-EPMC7225360 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
A Bitter Taste in Your Heart.
Bloxham Conor J CJ Foster Simon R SR Thomas Walter G WG
Frontiers in physiology 20200508
The human genome contains ∼29 bitter taste receptors (T2Rs), which are responsible for detecting thousands of bitter ligands, including toxic and aversive compounds. This sentinel function varies between individuals and is underpinned by naturally occurring T2R polymorphisms, which have also been associated with disease. Recent studies have reported the expression of T2Rs and their downstream signaling components within non-gustatory tissues, including the heart. Though the precise role of T2Rs ...[more]
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