System Approach for Building of Calcium-Binding Sites in Proteins.
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ABSTRACT:
SUBMITTER: Denesyuk AI
PROVIDER: S-EPMC7226230 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
System Approach for Building of Calcium-Binding Sites in Proteins.
Denesyuk Alexander I AI Permyakov Sergei E SE Johnson Mark S MS Denessiouk Konstantin K Permyakov Eugene A EA
Biomolecules 20200411 4
We introduce five new local metal cation (first of all, Ca<sup>2+</sup>) recognition units in proteins: Clamp<sub>n,(n-2)</sub>, Clamp<sub>n,(n-1)</sub>, Clamp<sub>n,n</sub>, Clamp<sub>n,(n+1)</sub> and Clamp<sub>n,(n+2)</sub>. In these units, the backbone oxygen atom of a residue in position "n" of an amino acid sequence and side-chain oxygen atom of a residue in position "n + i" (i = -2 to +2) directly interact with a metal cation. An analysis of the known "Ca<sup>2+</sup>-bound niches" in pro ...[more]
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