Ontology highlight
ABSTRACT:
SUBMITTER: Dokshin GA
PROVIDER: S-EPMC7227305 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Dokshin Gregoriy A GA Davis Gregory M GM Sawle Ashley D AD Eldridge Matthew D MD Nicholls Peter K PK Gourley Taylin E TE Romer Katherine A KA Molesworth Luke W LW Tatnell Hannah R HR Ozturk Ahmet R AR de Rooij Dirk G DG Hannon Gregory J GJ Page David C DC Mello Craig C CC Carmell Michelle A MA
Developmental cell 20191212 1
GCNA proteins are expressed across eukarya in pluripotent cells and have conserved functions in fertility. GCNA homologs Spartan (DVC-1) and Wss1 resolve DNA-protein crosslinks (DPCs), including Topoisomerase-DNA adducts, during DNA replication. Here, we show that GCNA mutants in mouse and C. elegans display defects in genome maintenance including DNA damage, aberrant chromosome condensation, and crossover defects in mouse spermatocytes and spontaneous genomic rearrangements in C. elegans. We sh ...[more]