Identification and Analysis of Dysfunctional Genes and Pathways in CD8+ T Cells of Non-Small Cell Lung Cancer Based on RNA Sequencing.
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ABSTRACT:
SUBMITTER: Tao X
PROVIDER: S-EPMC7227791 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
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Identification and Analysis of Dysfunctional Genes and Pathways in CD8<sup>+</sup> T Cells of Non-Small Cell Lung Cancer Based on RNA Sequencing.
Tao Xuefang X Wu Xiaotang X Huang Tao T Mu Deguang D
Frontiers in genetics 20200508
Lung cancer, the most common of malignant tumors, is typically of the non-small cell (NSCLC) type. T-cell-based immunotherapies are a promising and powerful approach to treating NSCLCs. To characterize the CD8<sup>+</sup> T cells of non-small cell lung cancer, we re-analyzed the published RNA-Seq gene expression profiles of 36 CD8<sup>+</sup> T cell isolated from tumor (TIL) samples and 32 adjacent uninvolved lung (NTIL) samples. With an advanced Monte Carlo method of feature selection, we ident ...[more]
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