Diffusion MRI reveals in vivo and non-invasively changes in astrocyte function induced by an aquaporin-4 inhibitor.
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ABSTRACT:
SUBMITTER: Debacker C
PROVIDER: S-EPMC7228049 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Diffusion MRI reveals in vivo and non-invasively changes in astrocyte function induced by an aquaporin-4 inhibitor.
Debacker Clement C Djemai Boucif B Ciobanu Luisa L Tsurugizawa Tomokazu T Le Bihan Denis D
PloS one 20200515 5
The Glymphatic System (GS) has been proposed as a mechanism to clear brain tissue from waste. Its dysfunction might lead to several brain pathologies, including the Alzheimer's disease. A key component of the GS and brain tissue water circulation is the astrocyte which is regulated by acquaporin-4 (AQP4), a membrane-bound water channel on the astrocytic end-feet. Here we investigated the potential of diffusion MRI to monitor astrocyte activity in a mouse brain model through the inhibition of AQP ...[more]
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