Ontology highlight
ABSTRACT:
SUBMITTER: Suma A
PROVIDER: S-EPMC7229852 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Suma Antonio A Stopar Alex A Nicholson Allen W AW Castronovo Matteo M Carnevale Vincenzo V
Nucleic acids research 20200501 9
We used coarse-grained molecular dynamics simulations to characterize the global and local mechanical properties of a DNA origami triangle nanostructure. The structure presents two metastable conformations separated by a free energy barrier that is lowered upon omission of four specific DNA staples (defect). In contrast, only one stable conformation is present upon removing eight staples. The metastability is explained in terms of the intrinsic conformations of the three trapezoidal substructure ...[more]