Ontology highlight
ABSTRACT:
SUBMITTER: Agema BC
PROVIDER: S-EPMC7230333 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Agema Bram C BC Koolen Stijn L W SLW With Mirjam de M Doorn Nadia van NV Heersche Niels N Hoop Esther Oomen-de EO Visser Sabine S Aerts Joachim G J V JGJV Bins Sander S Schaik Ron H N van RHNV Mathijssen Ron H J RHJ
Genes 20200327 4
Cisplatin is a chemotherapeutic agent widely used for multiple indications. Unfortunately, in a substantial set of patients treated with cisplatin, dose-limiting acute kidney injury (AKI) occurs. Here, we assessed the association of 3 catechol-O-methyltransferase (<i>COMT)</i> single nucleotide polymorphisms (SNPs) with increased cisplatin-induced nephrotoxicity. In total, 551 patients were genotyped for the 1947 G>A (Val158Met, rs4680), c.615 + 310 C>T (rs4646316), and c.616 - 367 C>T (rs933237 ...[more]