Oncogenic Linear Collagen VI of Invasive Breast Cancer Is Induced by CCL5.
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ABSTRACT:
SUBMITTER: Brett E
PROVIDER: S-EPMC7230614 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Oncogenic Linear Collagen VI of Invasive Breast Cancer Is Induced by CCL5.
Brett Elizabeth E Sauter Matthias M Timmins Éadaoin É Azimzadeh Omid O Rosemann Michael M Merl-Pham Juliane J Hauck Stefanie M SM Nelson Peter J PJ Becker Karl Friedrich KF Schunn Ilse I Lowery Aoife A Kerin Michael J MJ Atkinson Michael M Krüger Achim A Machens Hans-Günther HG Duscher Dominik D
Journal of clinical medicine 20200402 4
The triple-negative breast tumor boundary is made of aligned, linear collagen. The pro-oncogenic impact of linear collagen is well established; however, its mechanism of formation is unknown. An in vitro analogue of the tumor border is created by a co-culture of MDA-MB-231 cells, adipose derived stem cells, and dermal fibroblasts. Decellularization of this co-culture after seven days reveals an extracellular matrix that is linear in fashion, high in pro-oncogenic collagen type VI, and able to pr ...[more]
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