Overexpression of collagen VI ?3 in gastric cancer.

ABSTRACT: Collagen VI is significant in the progression of numerous types of cancer. Type VI collagen consists of three ?-chains and collagen VI ?3 (COL6A3) encodes the ?3 chain. The overexpression of COL6A3 has been demonstrated to correlate with high-grade ovarian cancer and contributes to cisplatin resistance; however, its role in human gastric cancer (GC) remains unclear. Using microarray meta-analysis, COL6A3 was observed to be frequently overexpressed in the GC tissues, furthermore, this overexpression was identified in five GC cell lines. A microarray-based co-expression network analysis was conducted and identified a total of 62 genes that were co-expressed with COL6A3, with the majority of the genes being involved in cancer-related processes, such as cell differentiation, migration and adhesion. Network analysis of these 62 genes demonstrated that fibronectin 1, a well-characterized oncogene, was located at the center of the COL6A3 co-expression network. Therefore, COL6A3 may act as an oncogene in human GC and the antagonism of COL6A3 may be an effective therapeutic treatment for GC.

SUBMITTER: Xie X 

PROVIDER: S-EPMC3997710 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature