Ontology highlight
ABSTRACT:
SUBMITTER: Battistini C
PROVIDER: S-EPMC6928865 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Battistini Chiara C Rehman Michael M Avolio Marco M Arduin Alessia A Valdembri Donatella D Serini Guido G Tamagnone Luca L
International journal of molecular sciences 20191127 23
Cadherins are a major family of cell-cell adhesive receptors, which are implicated in development, tissue homeostasis, and cancer. Here, we show a novel mechanism of post-translational regulation of E-cadherin in cancer cells by an intramembrane protease of the Rhomboid family, RHBDL2, which leads to the shedding of E-cadherin extracellular domain. In addition, our data indicate that RHBDL2 mediates a similar activity on VE-cadherin, which is selectively expressed by endothelial cells. We show t ...[more]