Do Antibiotics Potentiate Proteases in Hemotoxic Snake Venoms?
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ABSTRACT:
SUBMITTER: Sorensen CV
PROVIDER: S-EPMC7232225 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Do Antibiotics Potentiate Proteases in Hemotoxic Snake Venoms?
Sørensen Christoffer V CV Knudsen Cecilie C Auf dem Keller Ulrich Auf dem UAD Kalogeropoulos Konstantinos K Gutiérrez-Jiménez Cristina C Pucca Manuela B MB Arantes Eliane C EC Bordon Karla C F KCF Laustsen Andreas H AH
Toxins 20200409 4
Antibiotics are often administered with antivenom following snakebite envenomings in order to avoid secondary bacterial infections. However, to this date, no studies have evaluated whether antibiotics may have undesirable potentiating effects on snake venom. Herein, we demonstrate that four commonly used antibiotics affect the enzymatic activities of proteolytic snake venom toxins in two different in vitro assays. Similar findings in vivo could have clinical implications for snakebite management ...[more]
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