Ontology highlight
ABSTRACT:
SUBMITTER: Qu Y
PROVIDER: S-EPMC7232733 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Qu Yibai Y Yang Chunxiu C Li Xueyang X Luo Haihua H Li Shan S Niu Mengwei M Chen Peng P Yan Zhengzheng Z Jiang Yong Y
Oxidative medicine and cellular longevity 20200509
Oxidative stress and mitochondrial dysfunction are related to disease pathogenesis. Oligodeoxynucleotide containing CpG motifs (CpG ODN) demonstrate possibilities for immunotherapy applications. The aim of the present work is to explore the underlying mechanism of the cytoprotective function of CpG ODN by employing the oxidative stress modulation in immune cells. We used the imaging flow cytometry to demonstrate that tert-butyl hydroperoxide (t-BHP) induces mitochondrial-mediated apoptosis and R ...[more]