Ontology highlight
ABSTRACT:
SUBMITTER: Sun CP
PROVIDER: S-EPMC7233170 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Sun Cheng-Peng CP Zhang Juan J Zhao Wen-Yu WY Yi Jing J Yan Jian-Kun JK Wang Ya-Li YL Morisseau Christophe C Liu Zhong-Bo ZB Hammock Bruce D BD Ma Xiao-Chi XC
Bioorganic chemistry 20200129
The inhibition of soluble epoxide hydrolase (sEH) is a promising therapeutic approach to treat inflammation and other disorders. In our present investigation on searching for sEH inhibitors from traditional Chinese medicines, we found that Alisma orientale displayed inhibition of sEH. We constructed a small library of protostane-type triterpenoids (1-25) isolated from A. orientale, and screened their inhibitory activities. Alismanin B (1), 11-deoxy-25-anhydro alisol E (4), 11-deoxy alisol B (5), ...[more]