Ontology highlight
ABSTRACT:
SUBMITTER: Cerulli RA
PROVIDER: S-EPMC7233463 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Cerulli Robert A RA Kritzer Joshua A JA
Organic & biomolecular chemistry 20191128 4
Tyrosine phosphorylation is a critical component of signal transduction for multicellular organisms, particularly for pathways that regulate cell proliferation and differentiation. While tyrosine kinase inhibitors have become FDA-approved drugs, inhibitors of the other important components of these signaling pathways have been harder to develop. Specifically, direct phosphotyrosine (pTyr) isosteres have been aggressively pursued as inhibitors of Src homology 2 (SH2) domains and protein tyrosine ...[more]