Ontology highlight
ABSTRACT:
SUBMITTER: Saini N
PROVIDER: S-EPMC7234795 | biostudies-literature | 2020 Jul - Aug
REPOSITORIES: biostudies-literature
Regions of genomic DNA can become single-stranded in the course of normal replication and transcription as well as during DNA repair. Abnormal repair and replication intermediates can contain large stretches of persistent single-stranded DNA, which is extremely vulnerable to DNA damaging agents and hypermutation. Since such single-stranded DNA spans only a fraction of the genome at a given instance, hypermutation in these regions leads to tightly-spaced mutation clusters. This phenomenon of hype ...[more]