Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC4154566 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Wang Xiaohua X Fan Manxia M Kalis Susan S Wei Lirong L Scharff Matthew D MD
Nature communications 20140613
During somatic hypermutation (SHM), activation-induced deaminase (AID) mutates deoxycytidine on single-stranded DNA (ssDNA) generated by the transcription machinery, but the detailed mechanism remains unclear. Here we report a higher abundance of RNA polymerase II (Pol II) at the immunoglobulin heavy-chain variable (Igh-V) region compared with the constant region and partially transcribed Igh RNAs, suggesting a slower Pol II progression at Igh-V that could result in some early/premature transcri ...[more]