Ontology highlight
ABSTRACT:
SUBMITTER: De Majo F
PROVIDER: S-EPMC7235007 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
De Majo Federica F Hegenbarth Jana-Charlotte JC Rühle Frank F Bär Christian C Thum Thomas T de Boer Martine M Duncker Dirk J DJ Schroen Blanche B Armand Anne-Sophie AS Stoll Monika M De Windt Leon J LJ
Scientific reports 20200518 1
We investigated the transcriptomic landscape of the murine myocardium along the course of natural aging and in three distinct mouse models of premature aging with established aging-related cardiac dysfunction. Genome-wide total RNA-seq was performed and the expression patterns of protein-coding genes and non-coding RNAs were compared between hearts from naturally aging mice, mice with cardiac-specific deficiency of a component of the DNA repair machinery, mice with reduced mitochondrial antioxid ...[more]