Ontology highlight
ABSTRACT:
SUBMITTER: Mehta P
PROVIDER: S-EPMC7235846 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Life (Basel, Switzerland) 20200424 4
The histamine H<sub>4</sub> receptor, belonging to the family of G-protein coupled receptors, is an increasingly attractive drug target. It plays an indispensable role in many cellular pathways, and numerous H<sub>4</sub>R ligands are being studied for the treatment of several inflammatory, allergic, and autoimmune disorders, including pulmonary fibrosis. Activation of H<sub>4</sub>R is involved in cytokine production and mediates mast cell activation and eosinophil chemotaxis. The importance of ...[more]