Ontology highlight
ABSTRACT:
SUBMITTER: Barreto G
PROVIDER: S-EPMC7235883 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Barreto Goncalo G Manninen Mikko M K Eklund Kari K
Biology 20200330 4
Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In particular, chondrocyte-mediated inflammatory responses triggered by the activation of innate immune receptors by alarmins (also known as danger signals) are thought to be involved. Thus, toll-like receptors (TLRs) and their signaling pathways are of particular interest. Recent reports suggest that among the TLR-induced ...[more]