Ontology highlight
ABSTRACT:
SUBMITTER: Gerstner C
PROVIDER: S-EPMC7236297 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Gerstner Christina C Turcinov Sara S Hensvold Aase H AH Chemin Karine K Uchtenhagen Hannes H Ramwadhdoebe Tamara H TH Dubnovitsky Anatoly A Kozhukh Genadiy G Rönnblom Lars L Kwok William W WW Achour Adnane A Catrina Anca I AI van Baarsen Lisa G M LGM Malmström Vivianne V
BMC immunology 20200518 1
<h4>Background</h4>HLA class II tetramers can be used for ex vivo enumeration and phenotypic characterisation of antigen-specific CD4+ T cells. They are increasingly applied in settings like allergy, vaccination and autoimmune diseases. Rheumatoid arthritis (RA) is a chronic autoimmune disorder for which many autoantigens have been described.<h4>Results</h4>Using multi-parameter flow cytometry, we developed a multi-HLA class II tetramer approach to simultaneously study several antigen specificit ...[more]