Ontology highlight
ABSTRACT:
SUBMITTER: He T
PROVIDER: S-EPMC7237418 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
He Tianlin T Siwy Justyna J Metzger Jochen J Mullen William W Mischak Harald H Schanstra Joost P JP Zürbig Petra P Jankowski Vera V
Scientific reports 20200519 1
The polymeric immunoglobulin receptor (pIgR) transports immunoglobulins from the basolateral to the apical surface of epithelial cells. PIgR was recently shown to be associated with kidney dysfunction. The immune defense is initiated at the apical surface of epithelial cells where the N-terminal domain of pIgR, termed secretory component (SC), is proteolytically cleaved and released either unbound (free SC) or bound to immunoglobulins. The aim of our study was to evaluate the association of pIgR ...[more]