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Associations of urinary polymeric immunoglobulin receptor peptides in the context of cardio-renal syndrome.


ABSTRACT: The polymeric immunoglobulin receptor (pIgR) transports immunoglobulins from the basolateral to the apical surface of epithelial cells. PIgR was recently shown to be associated with kidney dysfunction. The immune defense is initiated at the apical surface of epithelial cells where the N-terminal domain of pIgR, termed secretory component (SC), is proteolytically cleaved and released either unbound (free SC) or bound to immunoglobulins. The aim of our study was to evaluate the association of pIgR peptides with the cardio-renal syndrome in a large cohort and to obtain information on how the SC is released. We investigated urinary peptides of 2964 individuals available in the Human Urine Proteome Database generated using capillary electrophoresis coupled to mass spectrometry. The mean amplitude of 23 different pIgR peptides correlated negatively with the estimated glomerular filtration rate (eGFR, rho?=?-0.309, p?

SUBMITTER: He T 

PROVIDER: S-EPMC7237418 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Associations of urinary polymeric immunoglobulin receptor peptides in the context of cardio-renal syndrome.

He Tianlin T   Siwy Justyna J   Metzger Jochen J   Mullen William W   Mischak Harald H   Schanstra Joost P JP   Zürbig Petra P   Jankowski Vera V  

Scientific reports 20200519 1


The polymeric immunoglobulin receptor (pIgR) transports immunoglobulins from the basolateral to the apical surface of epithelial cells. PIgR was recently shown to be associated with kidney dysfunction. The immune defense is initiated at the apical surface of epithelial cells where the N-terminal domain of pIgR, termed secretory component (SC), is proteolytically cleaved and released either unbound (free SC) or bound to immunoglobulins. The aim of our study was to evaluate the association of pIgR  ...[more]

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