Biological subtypes of Alzheimer disease: A systematic review and meta-analysis.

ABSTRACT:

Objective

To test the hypothesis that distinct subtypes of Alzheimer disease (AD) exist and underlie the heterogeneity within AD, we conducted a systematic review and meta-analysis on AD subtype studies based on postmortem and neuroimaging data.

Methods

EMBASE, PubMed, and Web of Science databases were consulted until July 2019.

Results

Neuropathology and neuroimaging studies have consistently identified 3 subtypes of AD based on the distribution of tau-related pathology and regional brain atrophy: typical, limbic-predominant, and hippocampal-sparing AD. A fourth subtype, minimal atrophy AD, has been identified in several neuroimaging studies. Typical AD displays tau-related pathology and atrophy both in hippocampus and association cortex and has a pooled frequency of

SUBMITTER: Ferreira D 

PROVIDER: S-EPMC7238917 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature