Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC7239699 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Chen Yangwu Y Shen Weiliang W Tang Chenqi C Huang Jiayun J Fan Chunmei C Yin Zi Z Hu Yejun Y Chen Weishan W Ouyang Hongwei H Zhou Yiting Y Mao Zhengwei Z Chen Xiao X
Science advances 20200429 18
Heterotopic ossification (HO) in connective tissues like tendons and ligaments severely damages tissue structure. The pathogenesis of HO remains unclear but may involve mTOR. The results presented here indicate that tendon stem/progenitor cells do not undergo osteochondrogenic differentiation when mTOR signaling is inactivated by gene knockout or rapamycin (RAPA) treatment. Meanwhile, it is necessary to deliver RAPA to the injured sites and avoid disturbing the normal tendon. A RAPA delivery sys ...[more]