Ontology highlight
ABSTRACT:
SUBMITTER: Agwae ME
PROVIDER: S-EPMC7239832 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Agwae Matthew E ME Shaw Richard J RJ Triantafyllou Asterios A Greaney Frances S T FST Ben Salah Khaled K Risk Janet M JM
Molecular biology reports 20200331 5
iRhom2 is an inactive rhomboid protease involved in diverse signalling events. It has been implicated in the pathogenesis of a number of cancer types, including oesophageal and ovarian cancer, while its closely associated family member, iRhom1, is implicated in head and neck cancer. However, a role for iRhom2 in head and neck cancer has not been investigated. Immunoblotting for iRhom2 in 54 oral squamous cell carcinoma (OSCC) and 24 paired normal tissues demonstrated higher levels of iRhom2 prot ...[more]