Histone H3K27M Mutation Overrides Histological Grading in Pediatric Gliomas.
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ABSTRACT:
SUBMITTER: Mosaab A
PROVIDER: S-EPMC7239884 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Histone H3K27M Mutation Overrides Histological Grading in Pediatric Gliomas.
Mosaab Amal A El-Ayadi Moatasem M Khorshed Eman N EN Amer Nada N Refaat Amal A El-Beltagy Mohamed M Hassan Zeinab Z Soror Sameh H SH Zaghloul Mohamed Saad MS El-Naggar Shahenda S
Scientific reports 20200520 1
Pediatric high-grade gliomas (HGG) are rare aggressive tumors that present a prognostic and therapeutic challenge. Diffuse midline glioma, H3K27M-mutant is a new entity introduced to HGG in the latest WHO classification. In this study we evaluated the presence of H3K27M mutation in 105 tumor samples histologically classified into low-grade gliomas (LGG) (n = 45), and HGG (n = 60). Samples were screened for the mutation in histone H3.3 and H3.1 variants to examine its prevalence, prognostic impac ...[more]
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