Ontology highlight
ABSTRACT:
SUBMITTER: Nichols CA
PROVIDER: S-EPMC7239950 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nichols Caitlin A CA Gibson William J WJ Brown Meredith S MS Kosmicki Jack A JA Busanovich John P JP Wei Hope H Urbanski Laura M LM Curimjee Naomi N Berger Ashton C AC Gao Galen F GF Cherniack Andrew D AD Dhe-Paganon Sirano S Paolella Brenton R BR Beroukhim Rameen R
Nature communications 20200520 1
Alterations in non-driver genes represent an emerging class of potential therapeutic targets in cancer. Hundreds to thousands of non-driver genes undergo loss of heterozygosity (LOH) events per tumor, generating discrete differences between tumor and normal cells. Here we interrogate LOH of polymorphisms in essential genes as a novel class of therapeutic targets. We hypothesized that monoallelic inactivation of the allele retained in tumors can selectively kill cancer cells but not somatic cells ...[more]