Selective Cyclized ?-Melanocyte-Stimulating Hormone Derivative with Multiple N-Methylations for Melanoma Imaging with Positron Emission Tomography.
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ABSTRACT:
SUBMITTER: Zhang C
PROVIDER: S-EPMC7240809 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
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Selective Cyclized α-Melanocyte-Stimulating Hormone Derivative with Multiple <i>N</i>-Methylations for Melanoma Imaging with Positron Emission Tomography.
Zhang Chengcheng C Zhang Zhengxing Z Zeisler Jutta J Colpo Nadine N Lin Kuo-Shyan KS Bénard François F
ACS omega 20200507 19
In this study, we designed and evaluated a novel α-melanocyte-stimulating hormone derivative with four <i>N</i>-methylations for melanocortin 1 receptor-targeted melanoma imaging with positron emission tomography (PET). The resulting peptide, DOTA-Pip-Nle<sup>4</sup>-Cyclo[Asp<sup>5</sup>-<i>N</i>-Me-His<sup>6</sup>-d-Phe<sup>7</sup>-<i>N</i>-Me-Arg<sup>8</sup>-<i>N</i>-Me-Trp<sup>9</sup>-<i>N</i>-Me-Lys<sup>10</sup>]αMSH<sub>4-10</sub>-NH<sub>2</sub> (CCZ01099), showed high receptor selectivity ...[more]
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