Development and external validation of a predictive scoring system associated with metastasis of T1-2 colorectal tumors to lymph nodes.

ABSTRACT:

Background

It is critical for determining the optimum therapeutic solutions for T1-2 colorectal cancer (CRC) to accurately predict lymph node metastasis (LNM) status. The purpose of the present study is to establish and verify a nomogram to predict LNM status in T1-2 CRCs.

Methods

A total of 16 600 T1-2 CRC patients were enrolled and classified into the training, internal validation, and external validation cohorts. The independent predictive parameters were determined by univariate and multivariate analyses to develop a nomogram to predict the probability of LNM status. The calibration curve, the area under the receiver operating characteristic curve (AUROC), and decision curve analysis (DCA) were used to evaluate the performance of the nomogram, and an external verificatio

SUBMITTER: Mo S 

PROVIDER: S-EPMC7240869 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature