Ontology highlight
ABSTRACT:
SUBMITTER: Ishizuka JJ
PROVIDER: S-EPMC7241251 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Nature 20181217 7737
Most patients with cancer either do not respond to immune checkpoint blockade or develop resistance to it, often because of acquired mutations that impair antigen presentation. Here we show that loss of function of the RNA-editing enzyme ADAR1 in tumour cells profoundly sensitizes tumours to immunotherapy and overcomes resistance to checkpoint blockade. In the absence of ADAR1, A-to-I editing of interferon-inducible RNA species is reduced, leading to double-stranded RNA ligand sensing by PKR and ...[more]