Unknown

Dataset Information

0

Elevated blood eosinophils in acute COPD exacerbations: better short- and long-term prognosis.


ABSTRACT: Background: Elevated eosinophils in COPD is recognized as a potential risk factor for exacerbations, but the prognostic role of elevated eosinophils during exacerbations of COPD is unclear. We investigated short-term and long-term outcomes in patients with exacerbations of eosinophilic phenotype, compared with patients with low blood eosinophils. Methods: A single-centre retrospective study of all patients admitted for a COPD exacerbation to Bispebjerg University Hospital in 2010-2011 was established by linking inpatient data with national patient and prescription registries, with a three-year follow-up period. Elevated eosinophils were defined as a blood eosinophil level at admission of ≥0.30 × 109 cells/L. Results: A total of 811 patients were included; 13.2% had an eosinophilic exacerbation. The eosinophilic group had less need for non-invasive ventilation, shorter inpatient stay, and lower in-hospital mortality, compared to the non-eosinophilic group. However, the eosinophilic and non-eosinophilic groups showed similar risks of readmission (incidence rate ratio[95], 0.99 [0.73-1.36]). Three-year mortality was high in both groups, although lower in the eosinophilic group (40% vs. 54%, p = 0.006). Conclusions: COPD exacerbations in patients with high blood eosinophil have a better short-term prognosis without higher risk of subsequent exacerbation. Eosinophilic exacerbations have also a lower three-year mortality.

SUBMITTER: Jabarkhil A 

PROVIDER: S-EPMC7241534 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6686508 | biostudies-literature
| S-EPMC8255541 | biostudies-literature
| S-EPMC4315304 | biostudies-literature
| S-EPMC5383071 | biostudies-literature
| S-EPMC4752631 | biostudies-other
| S-EPMC7269114 | biostudies-literature
| S-EPMC6245880 | biostudies-literature
| S-EPMC8848076 | biostudies-literature
| S-EPMC7406856 | biostudies-literature
| S-EPMC5764289 | biostudies-literature