Ontology highlight
ABSTRACT:
SUBMITTER: International Multiple Sclerosis Genetics Consortium
PROVIDER: S-EPMC7241648 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20190901 6460
We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the genetic architecture of MS that includes 200 autosomal susceptibility variants outside the major histocompatibility complex (MHC), one chromosome X variant, and 32 variants within the extended MHC. We used an ensemble of methods to prioritize 551 putative susceptibility genes that implicate multiple innate and adaptive pathways distributed across the cellular components o ...[more]